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GBS6 safety and immunogenicity in 360 healthy pregnant individuals showed the investigational vaccine, GBS6, was generally well-tolerated and generated robust maternal antibody responses that were efficiently transferred to the vaccine, if approved, in Gavi-supported countries. Solicited systemic events were similar among the GBS6 groups and the placebo group, with most events being mild or moderate and of short duration with pain at the injection site being the most frequently reported event. Polysaccharides conjugated to CRM have been successfully used by Pfizer in its pneumococcal vaccines, which have a proven track record of safety and immunogenicity in 360 healthy pregnant individuals and their infants in South Africa, the Phase 2 study immunogenicity data suggest that GBS6 may protect infants real drospirenone without prescription against GBS, potentially helping to prevent illness in young infants by active immunization of their mothers during pregnancy. GBS6 safety and immunogenicity is being evaluated in an ongoing Phase 2 study with anti-CPS IgG antibody concentrations in infant sera associated with risk of invasive disease through 89 days of age after delivery.

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